Journal of Cancer Science and Research
Open Access
ISSN: 2576-1447
ISSN: 2576-1447
Department of Pathology, Port Said University, Port Said, Egypt
Research Article
Assessment of Immunohistochemical Expression of CD44 and Osteopontin in Colorectal Adenoma and Colorectal Carcinoma
Author(s): Rasha Arafa Abdelamksoud Belel*, Mohamed O El Okda, Azza H M Zidan and Heba M Wagih
Objective: Colorectal Cancer (CRC) is a foremost global health concern and remains one of the major causes of cancer-related morbidity and mortality. It is the third most common cancer in adults after lung cancer and breast cancer worldwide. The theory that cancer originates from a subpopulation of tumor cells, named Cancer Stem Cells (CSC), they have important role of CSC in the initiation and maintenance of the tumor, as well as invasion, metastasis and therapeutic resistance. Among CSC markers, CD44 and OPN are two of the most investigated colorectal CSC markers and their proteins are introduced as the subpopulation with a greater tumorigenicity. This study aiming assessing the immunohistochemical expression of CD44 and OPN in colorectal adenomas and CRCs. And their relation between immunohistochemical expression of CD44 and OPN with tumor differentiation (grading).. View More»
DOI:
10.35248/2576-1447.23.8.543