Journal of Cancer Science and Research

Journal of Cancer Science and Research
Open Access

ISSN: 2576-1447

+44 7868 792050

Qing Chang

Department of Pathology and Laboratory Medicine, Henry Ford Health System, Detroit, MI, USA

  • Case Report   
    Medullary Carcinoma of Colon: Pathologists Dilemma
    Author(s): Kasturi Saikia*, Ejas Palathingal Bava and Qing Chang

    Medullary carcinoma of the colon is a rare tumor that has a unique and sometimes varied histologic profile, including a solid architecture with poor glandular differentiation, undifferentiated cellular morphology, an aberrant immunophenotype, and DNA microsatellite instability. Patients with medullary carcinoma have a better prognosis than those with other colon malignancies, but this rare tumor is often misdiagnosed. Here we report the case of a 77- year-old woman who presented with gastrointestinal bleeding and a 1-year history of anemia. A right-sided cecal mass was shown to harbor a tumor that had not spread to the lymph nodes. Interestingly, her tumor was positive for expression of Caudal-type homeobox transcription factor 2 (CDX2) and negative for the Keratin 20, which is unusual for this entity. However, overall cellular morphology and DNA microsatellite instability indicated b.. View More»
    DOI: 10.35248/2576-1447.23.8.532

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