Immunotherapy: Open Access

Immunotherapy: Open Access
Open Access

ISSN: 2471-9552

+44 1223 790975

Peng Han

Department of Proctology, Zaozhuang Hospital of Traditional Chinese Medicine, No 24 Gongsheng road, Shizhong District, Zaozhuang City, Shandong Province, 277100, China

  • Research Article   
    Comprehensive Analysis of Immune Related Genes in the Tumor Microenvironment of Colorectal Cancer
    Author(s): Deyu Chen, Peng Han and Feng Yang*

    Objective: This study was therefore designed to conduct a robust analysis of Colorectal cancer (CRC) immune microenvironment to identify specific genes and pathways that can be targeted in an effort to achieve more effective immunotherapy outcomes. Methods: Using five Independent data sets, we analyzed expression profiles associated with 29 different immune signatures, and we used these profiles to guide the hierarchical clustering of CRC samples based on their immune micro environmental composition Results: We were able to cluster our CRC samples based on whether they had exhibited high, medium, or low levels of infiltration by immune cell types associated with tumor clearance (Immunity-H, Immunity-M, and Immunity-L, respectively). Samples in the Immunity-H subset exhibited a “hot” immune.. View More»

    Abstract PDF