Journal of Cancer Science and Research
Open Access
ISSN: 2576-1447
ISSN: 2576-1447
Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Research Article
The Key proteins as potential effective biomarkers under Intraoperative Radiotherapy (IORT) in tumor bed of Breast Cancer patients
Author(s): Minoo Shahani, Jafar Shakeri, Ali Tafti, Farid Moradian, Majid Samsami, Pantea Rohollah, Atieh Akbari and Mohammad Esmaeil Akbari*
Background: Radiotherapy (RT) is recommended to all patients undergoing Breast Conserving Surgery (BCS). Two strategies can be applied to irradiation, External Beam RT (EBRT) in addition, Intraoperative Radiation Therapy (IORT). The aim of this study was to introduce a protein biomarker panel related to molecular function under IORT.
Methods: Six Breast Cancer (BC) patients as a pilot study were treated by 12 Gy (Boost dose) and 21 Gy (Radical dose). Samples tissue included Margin before IORT (MB), and Margin 24 hours After IORT (MA24 h). Isobaric Tag for Relative and Absolute Quantitation (iTRAQ) was performed to study proteomic of IORT-treated tumor bed.
Results: We classified 110 differentially expressed proteins (DEPs) as a protein biomarker panel by mapping the anno- tated coding region sequences t.. View More»
DOI:
10.35248/2576-1447.22.7.511