Journal of Molecular Pathology and Biochemistry

Journal of Molecular Pathology and Biochemistry
Open Access

Nazar M

Associate Professor, Hematology Department, Allied medical school, TUMS, Enqelab Ave, Tehran, Iran

  • Review Article   
    Study of Serum Thrombospondin-1 Level in Diabetic Patients with Diabetic Foot Ulcer
    Author(s): Alizadeh S*, Beige ZB, Poor Heravi SA, Nejad FS, Shokri MM and Nazar M

    Thrombospondins (TSP) are a group of multifunctional secretion proteins that consist of TSP-1 to TSP-5. TSP-1 is the first protein member of this family and a homotrimeric glycoprotein with a multifunctional domain. The aim of this study is to evaluate the level of TSP-1 and its impact on vessels in diabetic patients. In 2016, 90 diabetic patients were selected from Golestan hospital and Emam Khomeini hospital, they were put into three different groups; 30 patients (FBS over 126 mg/dL) without a diabetic foot ulcer (DFU) (group 1), 30 diabetic patients (FBS over 126 mg/dL) with a DFU (group 2), 30 people without diabetes or DFU (group 3). In all patients, Hemoglobin A1c (HbA1c), blood sugar, and TSP-1 tests were performed. Results: The mean amount of TSP-1 in group 1, 2, and 3 was 266.85 ± 88.75 ng/mL, 234.87 ± 129.8 ng/mL, and 1570.4.. Read More»

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