Department of Pediatrics, Shiraz University of Medical Sciences, Shiraz, Iran
Research Article
Increased Frequency of KIR2DS4 del/del among AA Genotype Carriers with B-Cell Acute Lymphoblastic Leukemia in Southwestern Iranian Population
Author(s): Sepide Namdari, Mohammad Reza Bordbar, Omid Reza Zekavat and Shirin Farjadian*
Acute Lymphoblastic Leukemia (ALL) is known to be the most common malignancy among children. The early onset of ALL suggests a key role of genetic factors in its development. Killer Cell Immunoglobulin-like Receptor (KIR) gene complex that encodes a group of key receptors expressed at the surface of natural killer cells has been of great interest as a possible genetic factor affecting the susceptibility to ALL. In this case-control study, we aimed to verify whether the inheritance of specific KIR genes or genotypes were associated with susceptibility to childhood B-ALL in southwestern Iranian population. To this end, KIR genotyping was carried out for 120 patients with childhood B-ALL and 170 unrelated healthy controls using PCR-SSP method. The frequencies of 11 KIR genes and KIR2DS4 variants were investigated among patients and healthy controls. We found no association between KIR ge.. View More»
DOI:
10.35248/igoa.21.6.134