Immunotherapy: Open Access

Immunotherapy: Open Access
Open Access

ISSN: 2471-9552

+44 1223 790975

Michele Malaguarnera

Research Center "The Great Senescence", University of Catania, 95100 Catania, Italy

  • Book Review   
    Exploring the Immunomodulatory Effects of Vitamin D3 in Sars-Cov2 Management
    Author(s): Michele Malaguarnera and Lucia Malaguarnera*

    Severe SARS-CoV2, the latest pandemic infectious diseases, is a serious threat to human health. SARS-CoV2 infection causes immune activation and systemic hyper-inflammation which can lead to respiratory distress syndrome (ARDS). ARDS victims are linked to sustained IL-6 and IL-1 increase. Macrophage activation associated with the “cytokine storm” promote the dysregulation of the innate immunity. So far without vaccines or specific therapy, all efforts to design drugs or clinical trials are deserving. Vitamin D and its receptor vitamin D receptor (VDR) exert an important role in infections for their remarkable impact on both innate and adaptive immune responses and on the suppression of inflammatory process. The protective effects of vitamin D supplementation have been proved by several observational studies and by meta-analysis of clinical trials for p.. View More»

    Abstract PDF