Department of Dentistry and Oral Health, Griffith University, Griffith, Australia
Research Article
Is There Link between Kaposi?s Sarcoma-Associated Herpes Virus (KSHV) in Group of Male Oral Squamous Cell Carcinoma Patients with Established Risk Factors in Non-Endemic Sri Lanka? Evidence from a Case-Control Study
Author(s): Manosha Lakmali Perera*, Irosha Rukmali Perera and Ranjith Lal Kandewatte
Head and Neck Cancers (HNSCCs) are established as looming public health challenge and health economic burden as the 8th most common cancer type according to a 2020 global estimation. Of them, Oral Squamous Cell Carcinoma (OSCC) ranks as the number 1 histologically diagnosed type of oral malignancy with 90%-95% prevalence across the globe. The geographic and population specificity is common in oral cancer patients as well as patients infected with the Kaposi’s Sarcoma-Associated Herpes Virus (KSHV). Hence, KSHV infections among immunosuppressive patients are higher in endemic areas than in non-endemic areas. Moreover, KSHV associated carcinomas are common among patients suffering from Acquired Immune Deficiency Syndrome (AIDS). Here we hypothesized that immunosuppression in oral cancer patients could elevate the transcription and active transmission of oncogenic &gamma.. View More»
DOI:
10.35248/IGOA.23.8.219