Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
ISSN: 2155-9880
Department of of Emergency Medicine, AIIMS, Delhi, India
Mini Review
A Brief Review of Familial Hypercholesterolemia
Author(s): Krishna Prasad Akkineni*, Mohan Prasad Akkineni, Goutam Kintada, Souvik Sardar and Maithili Charan Gattu
Familial Hypercholesterolemia (FH) is an autosomal codominant disorder characterized by elevated levels of LowDensity Lipoprotein Cholesterol (LDL-C). It manifests in both heterozygous and homozygous forms, most commonly due to loss-of-function mutations in the LDL receptor gene. Lifelong exposure to elevated LDL-C leads to premature and accelerated atherosclerosis, particularly in homozygous individuals. This review summarizes current diagnostic criteria for FH, explores the spectrum of coronary artery involvement, and outlines the expanding therapeutic landscape... View More»
DOI:
10.35248/2155-9880.25.16.964