Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Department of Pharmacy and Pharmaceutical Sciences, Islamic Azad University Tehran Medical Science (IAUTMU), Tehran, Iran
Research Article
Probiotics as a Complementary Method in Accelerating the Treatment of Opioid Poisoning: A Clinical Trial with Lactobacillus and Bifidobacterium Strains
Author(s): Mahnaz Tajdari, Mitra Rahimi, Shahin Shadnia and Peyman Erfan Talab Evini*
Introduction: The amount of opioids used in Iran is estimated at one million and two hundred thousand people. Probiotic force-feeding containing Lactobacillus acidophilus and Bifidobacterium bifidum can increase the effectiveness of initial treatment and intravenous naloxone as an antidote and accelerate recovery.
Materials and methods: In this randomized controlled clinical trial study, 30 patients with acute opioid poisoning were studied. In addition to treatment with naloxone and other control therapies, half of the patients were treated with probiotics and the other half with placebo. Patients were randomly assigned to one of the two case or control groups and the case group underwent standard probiotic force-feeding every eight hours for seven days. Data from the study were analyzed by SPSS software version 16. Results.. View More»
DOI:
10.35248/2161-0495-22.S22.001