Advancements in Genetic Engineering
Open Access

Department of Cardiology, Chengdu Xinhua Hospital, Sichuan, China

Publications

• Research Article   
  The Hereditary Fusion Genes are Associated with the Inheritance of Acute Myeloid Leukemia
  Author(s): Ling Fei, Jinfeng Yang, Noah Zhuo and Degen Zhuo*
  
  Fusion genes had been thought to be somatic and cause cancer, including Acute Myeloid Leukemia (AML). Validating highly-recurrent fusion genes in healthy samples compelled us to systematically study Hereditary Fusion Genes (HFGs). Here, we used the previously-curated 1180 HFGs from Monozygotic (MZ) twins to analyze total fusion transcripts from AML patients and identified 926 (78.5%) HFGs overlapped with AML. We selected 242 HFGs ranging from 10% to 83.3% to perform comparative analysis and showed that 239 HFGs were significantly higher than their counterparts of Genotype-Tissue Expression (GTEx) blood samples and associated with AML inheritances. A 5’-gene and 3’-gene were fused with multiple 3’-genes and 5’-genes, respectively, to form biological networks and result in potential hyper susceptibility to somatic genetic and environmental ab.. View More»
  DOI: 10.35248/2169- 0111.23.12.214

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