Journal of Cell Science & Therapy
Open Access
ISSN: 2157-7013
ISSN: 2157-7013
Department of Gerontology and Systems Biology, AntiCA Biomed, San Diego, California, United States
Research Article
DNA Methylation Meta-Analysis Confirms the Division of the Genome into Two Functional Groups
Author(s): Lev Salnikov*, Saveli Goldberg, Parvathy Sukumaran and Eugene Pinsky
Based on a meta-analysis of human genome methylation data, we tested a theoretical model in which aging is explained by the redistribution of limited resources in cells between two main tasks of the organism: its selfsustenance based on the function of the Housekeeping Gene Group (HG) and functional differentiation, provided by the (IntG) integrative gene group. A meta-analysis of methylation of 100 genes, 50 in the HG group and 50 in IntG, showed significant differences (p<0.0001) between our groups in the level of absolute methylation values of genes bodies and its promoters. We showed a reliable decrease of absolute methylation values in IntG with rising age in contrast to HG, where this level remained constant. The one-sided decrease in methylation in the IntG group is indirectly confirmed by the dispersion data analysis, which also decreased in the genes of this group. The imb.. View More»
DOI:
10.35248/2157-7013.22.S10.352