Andrology-Open Access
Open Access

Department of Chemistry, Kuwait University, Kuwait City, Kuwait

Publications

• Research Article   
  Nano LDL Drug Delivery Systems of Triazole Derivatives: Synthesis, Characterization, Anticancer Evaluation and Insilico Investigation Targeting HER2 and β-Tubulin Proteins
  Author(s): Laila A. Jaragh-Alhadad*
  
  In medicinal chemistry, the 1,2,4-triazole scaffold has a wide spectrum of applications. Using this scaffold to synthesize new derivatives as anticancer agents targeting proliferation proteins like HER2 and β-tubulin and delivered by nano-LDL particles to specific sites is an attractive approach. The 1,2,4-triazole derivatives were fully characterized, an x-ray single crystal confirmed the structure of agent 4f and the morphologies were studied to prove the particles’ nano size. The agents were encapsulated into nano-LDL particles, to benefit from the lipid metabolic pathway and the nano-particle size showed an increase after encapsulation. The biological results in the present study showed that 1,2,4-triazole derivatives have anticancer activity toward both breast (MDA468) and prostate (DU145) cancer cell lines. The molecular docking technique was used to predict the poten.. View More»
  DOI: 10.35248/2167-0250.25.14.351

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