Clinical & Experimental Cardiology
Open Access
ISSN: 2155-9880
ISSN: 2155-9880
Department of Pediatrics, School of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan
Research Article
Pulmonary Expression of Non-Canonical Wnt Signaling is Upregulated in Pulmonary Hypertension Secondary to Left Ventricular Dysfunction
Author(s): Jao-Yu Lin, Yi-Ching Liu, Chee-Yin Chai, I-Chen Chen, Jwu-Lai Yeh, Jong-Hau Hsu, Bin-Nan Wu* and Zen-Kong Dai*
Pulmonary hypertension is a life-threatening progressive disease with few curable therapies due to its diversity and complexity. It results from increased pulmonary vascular tone and pulmonary vascular remodelling, with the aberrant Proliferation and Migration of Smooth Muscle Cells (PASMCs). The pulmonary vascular remodelling is more crucial than vasoconstriction in the development of human PH. Wnt is a family of secreted glycoproteins with varied expressions and functions. Its signalling, divided into the canonical and the non-canonical pathways, can regulate cell proliferation and cell migration pathways. Altered Wnt expressions can result in dysregulated cellular proliferation through extracellular receptors. The reactivation of fetal Wnt genes seen in embryonic development has been reported in a wide range of human pathologies, including cancers and lung disease. The exact mechan.. View More»
DOI:
10.35248/2155-9880.23.14.851