Anesthesia & Clinical Research

Anesthesia & Clinical Research
Open Access

ISSN: 2155-6148

Jin Tao

Department of Physiology and Neurobiology, Medical College of Soochow University, Suzhou, China

  • Mini Review   
    Neuropathic Pain: Mirna-547-5p-Mediated IL-33/ST2 Signaling and Bone Marrow Stromal Cell Therapy
    Author(s): Ju Zhou, Jin Tao, Xian-Min Yu*, Xinghong Jiang

    We have recently identified that the depression of MicroRNA (miRNA)-547-5p, which can be induced by a Chronic Constriction Nerve Injury (CCI), is an upstream event causing the enhancement of interleukin-33 (IL-33)/ Suppressor Tumorigenicity 2 (ST2) signaling and leading to pain hypersensitivity in rats. Moreover, the application of Bone Marrow Stromal Cells (BMSCs) reduces CCI-induced pain hypersensitivity by blocking the depression of miRNA-547-5p or its downstream molecules IL-33 and ST2. The roles of the miRNA-547-5p/IL-33/ST2 signaling pathway in the genesis of neuropathic pain and the analgesic effects of treatment with BMSCs are further discussed in this mini-review... View More»
    DOI: 10.35248/2155-6148.21.12.1026

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