Journal of Infectious Diseases & Preventive Medicine
Open Access
ISSN: 2329-8731
ISSN: 2329-8731
National Reference Laboratory, Rwanda Biomedical Centre, Kigali, Rwanda
Research Article
The Interleukin-6 and Interleukin-10 Plasma Levels the Driver of Immune Dysfunction and Chronic Inflammation in HIV Infection
Author(s): Jean Pierre Ngangali*, Leon Mutesa, Sabin Nsanzimana, Jean Bosco Munyemana, Emonyi Wilfred Injera, Patel Kirtika, Swaibu Gatare, Robert Rutayisire, Isabelle de Valois Ndishimye, Pacifique Ndishimye, Edouard Ntagwabira, Lilian Nkinda and Alex K Chemtai
Background: Cytokines network drive Human Immunodeficiency Virus (HIV) inflammation and pathogenesis.
Highly Active Antiretroviral Therapy (HAART) maintains low HIV viral load (VL) but chronic inflammation remains
high in HIV subjects compared to HIV naïve population. To date, there is no surrogate biomarker that gives the
hallmark picture of immune activation, chronic inflammation in HIV programs. This study aimed at determining the
plasma cytokine levels and their association with HIV VL at initiation and after six months on HAART in Rwanda.
Methods: We used a matching groups approach based on sex and systematic sampling within the groups was used
to enrol fifty (50) patients in each group. Fifteen (15) HIV naive people were included in the study as control group.
BD Flow cytometry was used to determine cytokine levels.. View More»