Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Department of Medicine, Northeast Ohio Medical University, Rootstown, Ohio, United States
Mini Review
A Trial of Therapeutic Plasma Exchange in Intramuscular Ricin Poisoning
Author(s): Bhavya Sharma, Jay Patel, Timothy Schaub, Joseph Myers and Rupesh Raina*
Ricin poisoning is an exceedingly rare clinical scenario encountered in the field of toxicology. Potential routes of
exposure consist of injection, inhalation, or ingestion. The ricin toxin’s mechanism of action involves inhibition of
protein synthesis, and the corresponding clinical findings can include nausea, vomiting, shortness of breath,
pulmonary edema, cutaneous and visceral necrosis, multi-organ failure, and sepsis. Renal failure is often
encountered, and the appropriate management is not currently established in the literature. We report a fatal case of
intramuscular ricin injection leading to renal failure in a 37-year-old male. To our knowledge, there has been only one
prior confirmed lethal case of intramuscular poisoning. Our case is also the first to evaluate the efficacy of Plasma
Exchange (PLEX) in adult ricin poisoning. Although treatment r.. View More»
DOI:
10.35248/2161-0495.21.11.492