Journal of Proteomics & Bioinformatics
Open Access
ISSN: 0974-276X
ISSN: 0974-276X
Department of Proteomics and Bioinformatics, Children’s Hospital of Philadelphia, University of Pennsylvania, Philadelphia, United States
Perspective
Urine Proteomics: Future Diagnostic Tool for Kidney Related Diseases
Author(s): Hossein Fazelinia*
The non-invasive nature of urine collection makes urinary proteins an ideal biomarker for diagnosing kidney disease and other diseases associated with the urinary tract, such as prostate and bladder cancer. Urine is one of the most attractive biofluids in clinical proteomics because it can be obtained noninvasively in large quantities and is stable compared to other biofluids. The urinary proteome has been studied using almost all proteomics techniques, but mass spectrometry-based profiling of urinary proteins and peptides has emerged as the most suitable for clinical application. After a period of descriptive urinary proteomics, the field is moving out of the discovery stage and into an era of validation of urinary biomarkers in larger prospective studies. Although primarily based on the location of urine production, most of these studies relate to the kidney and urinary tract, recen.. View More»
DOI:
10.35248/0974-276X.23.16.646