Andrology-Open Access
Open Access
ISSN: 2167-0250
ISSN: 2167-0250
Department of Reproductive Biology, University Hospital Farhat Hached, Sousse, Tunisia
Review
The Contribution of Antioxidant Treatment on Sperm Parameters, DNA Integrity and ICSI Results
Author(s): Marwa Lahimer*, Oumaima Gherissi, Henda Mustapha, Samira Ibala, Hédi Khaïri, Hafida Khorsi Cauet, Moncef BenKhalifa, Habib Ben Ali and Mounir Ajina
In the etiology of male infertility, Oxidative Stress (OS) is a major cause of semen decline. The association between OS and male infertility is well known, estimated to be present at elevated levels in as many as 30%-80% of men experiencing infertility. Spermatozoa are particularly susceptible to oxidative damage due to their high content of polyunsaturated fatty acids and limited capacity for antioxidant defense mechanisms. OS occurs when there is an imbalance between the production of Reactive Oxygen Species (ROS) and the body's ability to neutralize or repair their harmful effects. Accumulating evidence suggests that OS contributes to lipid peroxidation, protein oxidation, mitochondrial dysfunction, and genome decay. Antioxidant treatments play a crucial role in mitigating OS by scavenging free radicals and preventing cellular damage. Effective clinical decision-making require.. View More»
DOI:
10.35248/2167-0250.24.13.312