Journal of Clinical and Experimental Cardiology
Open Access
ISSN: 2155-9880
ISSN: 2155-9880
Presbyterian Saint Luke's Medical Center, Denver, Ethiopia
Short Communication
Correction of Oxygen-Nutrient Mismatch Might Account for the Beneficial Effect of Obeticholic Acid in NASH
Author(s): Gerond Lake-Bakaar*
The Farnesoid X Receptor (FXR) is a nuclear bile acid receptor involved in bile acid homeostasis, hepatic and intestinal inflammation, liver fibrosis, and cardiovascular disease. Obeticholic Acid (OCA), a potent, selective FXR agonist decreases portal hypertension in animal models of cirrhosis [1,2]. The drug is also effective in the treatment of non-alcoholic steatohepatitis, NASH [3-5]. The two disparate findings might be reconciled by an effect of OCA on hepatic artery flow... View More»
DOI:
10.35248/2155-9880.22.13.746