Lupus: Open Access
Open Access
ISSN: 2684-1630
ISSN: 2684-1630
Department of Obstetrics and Gynecology, IRCCS Foundation Policlinico San Matteo, University of Pavia, Italy
Research
Effect of Known and Previously Undiagnosed Undifferentiated Connective Tissue Diseases on Pregnancy Outcome
Author(s): Fausta B, Elena L*, Chiara C, Véronique R, Camilla B, Irene DM, Beatrice R, Carlomaurizio M and Arsenio S
Objective: Previously undiagnosed and known UCTDs are associated with severe obstetric and perinatal outcomes compared to controls.
Methods: Previously undiagnosed UCTDs and controls were screened using a two-step approach (selfadministered questionnaire and test for rheumatic autoantibodies) and evaluation by a rheumatologist. Pregnant subjects with known UCTD were recruited at the first trimester of pregnancy during their rheumatologic follow-up. Pregnancy complications such as preeclampsia, fetal growth restriction, small for gestational age, umbilical artery PI>95th percentile, prematurity<37 weeks ’gestation, were evaluated in cases and controls.
Results: Out of the 5199 women screened, 114 (2.2%) had a previously undiagnosed UCTD and 65 (1.25%) were diagnosed with major connective tissue diseases. Wom.. View More»