Journal of Depression and Anxiety
Open Access

Department of Psychiatrist and Professor of Psychiatry, Universisty of Santo Amaro (UNISA), São Paulo, Brazil

Publications

• Review   
  The Effects of Lithium on the Endogenous Opioid System: A Model for Nonsuicidal Self-Injury Behavior
  Author(s): Décio Gilberto Natrielli-Filho*
  
  Lithium and the opioid system have been studied extensively in the field of neuroscience due to their potential therapeutic applications in treating a range of psychiatric disorders. Lithium's mechanism of action is not fully understood, but it is believed to involve multiple neurotransmitter systems. The opioid system may also be involved, as lithium has been shown to modulate the effects of opiates in animal studies. Lithium is commonly used to treat bipolar disorder, while opioid receptors have been implicated in analgesia, regulation of mood and behavior. Studies from the last four decades have suggested that lithium may modulate the activity of the opioid system, and this interaction may play a role in the therapeutic effects of this ion. This review will explore the current understanding of the interaction between lithium and the opioid system, and discuss t.. View More»
  DOI: 10.35248/2167-1044.23.12.506

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