Journal of Clinical Toxicology
Open Access

Department of Medicine, N. I. Pirogov Russian National Research Medical University, Moscow, Russia

Publications

• Research Article   
  An Advanced In Silico Model to Optimize the Pharmacokinetic Studies ON ²⁵Mg ²⁺-Releasing Porphyrin-Fullerene Nanoparticles in Brain Ischemic Disorders
  Author(s): Valentin V Fursov*, Daria Namestnikova and Dmitriy A Kuznetsov
  
  The In Silico study on neuropharmacokinetiks of some novel porphyrin-fullerene based 25 Mg 2+ nanocarriers was performed to optimize the preclinical research path required for both prevention and correction of brain ischemic stroke-related metabolic disorders such us ATP depletion and its direct consequences. Thus, the local brain tissue hypoxia scenario is in a focus of this novel analytical approach suitable for the prediction of some parameters of the 25 Mg-magnetic isotope effect promoted antihypoxic activities as long as they relate upon delivery, distribution and intralization of the low toxic/amphiphilic Mg 2+ -releasing nanoparticles of PMC16 type. This is the first report ever on a mathematical model applied to predict and prove a mere phenomenon of the “cellular pump” keeping the constant traffic of PMC16 particles towards a brain hypoxia area even when/.. View More»
  DOI: 10.35248/2161-0495.23.13.546

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