Journal of Developing Drugs
Open Access
ISSN: 2329-6631
ISSN: 2329-6631
Department of Pharmacology, Enugu State University of Science and Technology, Enugu State, Nigeria
Daniel Lotanna Ajaghaku works at Enugu State University of Science and Technology · Department of Pharmacology. His publications are Estrogenic and safety evaluation of root extract of Millettia aboensis as a potential plant derived alternative for hormone replacement therapy, Tropical Journal of Natural Product Research Molucidine and Desmethylmolucidine as Immunostimulatory Lead Compounds of Morinda lucida (Rubiaceae), Curr Res Diabetes Obes J Millettia aboensis Attenuates Diabetes Induced Systemic Oxidative Stress in Experimental Animal Model and etc.
Research Article
Low-Dose 17?-Estradiol Supplemented with Andrographis Paniculata Improved Glucose and Lipid Homeostasis in a Type-2 Diabesity Mice Model
Author(s): Ikechukwu Sonne Mbagwu, Obiora Celestine Ugwu, Uchechukwu Harrison Orji, Raymond Ogbonna Offiah and Daniel lotanna Ajaghaku*
Estrogens play an important role in metabolic homeostasis. However, its risk of oncogenecity and cardiovascular adverse effects underscores its therapeutic benefits. This study investigated the metabolic effect of low dose estrogen supplemented with Andrographis paniculata on type-2 diabesity mice model. The experimental animals maintained on high fat diet were induced diabetes with streptozotocin (100 mg/kg) after intraperitoneal injection of 50 mg/kg nicotinamide. Low dose estrogen (0.02 mg/kg) was administered alone as well as in combination with 50, 150 and 500 mg/kg of the ethanol extract of A. paniculata. These doses of the extract, vehicle (5 ml/kg distilled water) and two reference standards pioglitazone (30 mg/kg) and metformine (100 mg/kg) were used as controls. Oral glucose tolerance test was used to determine the effect of treatment on pancreatic β-cell function and i.. View More»
DOI:
10.35248/2329-6631.21.10.204