Journal of Cancer Science and Research
Open Access
ISSN: 2576-1447
ISSN: 2576-1447
Department of Cancer biology and research at The University of Tokyo, Japan
Editorial
Rational Combinations of Active and Passive Immunotherapy Mobilize Immune and Clinical Responses in Terminal Cancers
Author(s): Chikuda Junichiro*
Solid tumors encroach on the hosts immune microenvironment to favor its own proliferation. Strategies to enhance the specificity of the endogenous T cell population against tumors have been met with limited clinical success. We aimed to devise a 2-tier protocol coupling in vivo whole antigen priming with ex vivo cellular expansion to clinically evaluate survival in patients following re-infusion of primed, autologous T cells, determining treatment efficacy. Treatment commenced with the acquisition of whole tumor antigens from tumor cell lines corresponding with patients primary malignancy. Lysate mixture was inoculated intradermally while Peripheral Blood Mononuclear Cells (PBMCs) were periodically extracted via phlebotomy and expanded in culture ex vivo for re-infusion. Post treatment tumor- specific T cell response and cytotoxicity was confirmed via ELI Spot and Real-Time Cell Analy.. View More»