Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
+44 1478 350008
ISSN: 2161-0495
+44 1478 350008
Department of Pharmacology and Toxicology, NnamdiAzikiwe University, Anambra, Nigeria
Research Article
Evaluation of the Effect of Luteolin on the Hepatic and Hematopoietic Systems in Albino Rats
Author(s): Chima Ernest Orji, Chinaza Kindness Okpoko, Chukwuemeka Amechi Agbata, Jude Nnaemeka Okoyeh*, Anthony Chimezie Okeke and Chibueze Peter Ihekwereme
Background: Luteolin is a flavonoid with some useful pharmacological properties yet its safety profile has not been
fully delineated .Objectives of the study were to investigate the effects of luteolin on blood and liver functions, and
make necessary recommendations regarding therapeutic use of luteolin.
Methods: A total of 33 adult albino rats (average weight) were used in this study. Oral LD50 of luteolin was carried
out with 13 rats using modified Lorke’s method. The other 20 rats were divided into 4 groups comprising of 5 rats
per group (n=5 per group) for biochemical, haematological and histopathological studies which were carried out for
28 days. Group I was used as control and received orally 10 ml/kg of distilled water. Groups II,III and IV also orally
received 50 mg/kg,100 mg/kg and 200 mg/kg of luteolin re.. View More»
DOI:
10.35248/2161-0495.20.10.434