Andrology-Open Access
Open Access
ISSN: 2167-0250
ISSN: 2167-0250
Department of Medicine, Xiamen Health and Medical Big Data Center (Xiamen Medicine Research Institute), Xiamen, Fujian, 361000, China
Mini Review
A Mini-Review of Sildenafil's Paradoxical Roles in Oncology
Author(s): Bin Zhao, Meiqi Lu, Zhijin Li, Caobin Ma, Yongquan Lu, Yan Wang, Anran Sun and Zheng Wan*
Sildenafil, a renowned Phosphodiesterase type 5 (PDE5) inhibitor, has a well-established role in managing erectile dysfunction by promoting Nitric Oxide (NO)-mediated relaxation of the corpus cavernosum. Beyond its urological applications, emerging research underscores its anti-tumoral efficacy in diverse cancers. However, concerns arise from its potential pro-tumoral role, with several studies indicating an association between Sildenafil use and increased melanoma risk. Although causality remains debated, the drug's dual oncological potential necessitates a discerning evaluation of its therapeutic application. This mini-review seeks to amalgamate information about the therapeutic and anti-tumor consequences of sildenafil in oncology, aiming to furnish guidance for its more prudent use... View More»
DOI:
10.35248/2167-0250.25.14.342