Emergency Medicine: Open Access
Open Access

Department of Cardiology, The Second Hospital of Jilin University, Changchun, China

Publications

• Research Article   
  A Mendelian Randomization Study Investigated the Association between Socioeconomic Status and the Risk of Myocardial Infarction.
  Author(s): Qiang Luo, Meijia Liu, Xueqing Sun, Longbo Li, Guan Wang, Yongfeng Shi* and Bin Liu
  
  Background: The causal relationship between socioeconomic factors and the risk of cardiovascular disease is not well understood. We applied a two sample Mendelian Randomization (MR) to find the causal link between Socioeconomic Status (SES) and the risk of Myocardial Infarction (MI) using data from large scale Genome-Wide Association Studies (GWAS) of socioeconomic status and myocardial infarction. Method: Using a two sample MR design, the genetic tools for the exposure SES and the outcome MI were gathered from different GWAS data sources. We first identified the causal effect of the socioeconomic determinants on SES and then investigated the causal relationship between SES and MI. Inverse variance weighted method, weighted median method, MR-Egger regression, MR Pleiotropy RESidual Sum and Outlier test were used for MR analyses. .. View More»
  

  Abstract PDF