Shagreen Health Life Sciences Ltd. Yenisehir Mah, Mehmet Nurdag Cad, Teras 2 Apt No: 28/26 Artuklu, Mardin, Turkey
Review Article
Systemic Organ Involvement and Retinoid Signaling Disorder in COVID-19
Author(s): Aziz Rodan Sarohan*
Although more than a year has passed since the COVID-19 outbreak, the pathogenesis of the disease has not yet
been clearly explained. The way to develop effective vaccines and drugs against the disease depends on a clear
elucidation of the pathogenesis. Therefore, the underlying mechanism of COVID-19 pathogenesis has been one
of the most curious and studied topics since the beginning of the pandemic. Systemic organ involvement in
COVID-19 cannot be explained by viral tropism mediated by ACE2 and TMPRSS2. Many chronic, inflammatory,
and autoimmune diseases such as autism, dementia, and memory problems that emerged late after COVID-19 have
made the pathogenesis of COVID-19 even more mysterious. Our studies and current literature show that the main
problem in the pathogenesis of COVID-19 is retinol depletion and retinoid signal impairment. It is understood that
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DOI:
10.35248/igoa.21.6.145
