Journal of Glycobiology
Open Access
ISSN: 2168-958X
ISSN: 2168-958X
Department of Pediatric Hematologic Oncology and BMT, Sultan Qaboos University Hospital, Muscat, Oman
Review Article
Glycobiology-Targeted Therapies in Hematologic Oncology: Ushering in a New Era of Cancer Diagnostics and Therapeutics
Author(s): Ashraf Abdullah Saad*
Despite that immunotherapy revolutionized cancer treatment, a considerable proportion of patients do not respond. While scientists continued to make perpetuating efforts in order to associate, glycans (carbohydrates) have come under scrutiny as the next frontier in pharmaceutical research. Immunologically speaking, tumor specific glycan signatures that mediate tumor cell recognition by the immune system offer novel immunotherapy targets for developing both specific and powerful therapeutic strategies against cancer. Notwithstanding that we are lately witnessing breakthrough discoveries in glycan-targeting therapies for solid tumors being reported in a substantial number of studies, the utilization of these therapies in liquid tumors (i.e., leukemia, lymphoma and myeloma) continued to lag far behind. On the other hand, humoral and cellular immunotherapeutic agents were quite successful.. View More»