Internal Medicine: Open Access
Open Access
ISSN: 2165-8048
ISSN: 2165-8048
Department of Medicine, Regional Medical Affairs, Pfizer Corporation Hong Kong Ltd, Quarry Bay, Hong Kong
Research Article
Development of Novel Folate Conjugated Nanoparticles Based Skin Lotion for Skin
Cancer Treatment: in vitro Characterization and In vivo Study
Author(s): Anshita Gupta, Chanchal Deep Kaur, Shailendra Saraf and Saraf Swarnlata*
Quercetin a natural flavanoid has been extensively investigated for its anticancer activity. However, the major disadvantage remained its poor aqueous solubility. In the present research, we investigated the efficacy of folate conjugated quercetin nanoparticles in vitro and further formulated its lotion and studied its skin permeation ability with In vivo activity. The in vitro cellular uptake and antiproliferative potentials of folate conjugated quercetin nanoparticles were evaluated using HaCaT, KB and A431 cell lines. The results showed robust cellular uptake of folate conjugated quercetin nanaoparticles by cell lines. ROS study and Intracellular GSH study revealed that folate conjugated Qu-NPs remarkably reduces the intracellular reactive oxygen species generation and release of GSH. Cells viability studies showed that folat.. View More»
DOI:
10.35248/2165-8048.22.12.357