Open Access
ISSN: 1234-5678
ISSN: 1234-5678
Department of Pathology, Wellington Hospital, Wellington, New Zealand
Research Article
Cell Wall Deficient Mycobacteria (CWDM) in Blood Myelocytes and Brain Tissue in Late Onset Alzheimer?s Disease (AD) Implications for New Approaches in Drug Development
Author(s): William Chamberlin*, Andrew Tie, Christopher Fowler, Lawrence Ward and John Aitken
Introduction: The presence of cell wall deficient Mycobacteria (L-Form) infections in macrophages and Alzheimer
brain tissue is not currently recognized.
Methods: Elderly subjects were selected from the Australian Imaging, Biomarker and Lifestyle study of ageing and
grouped as MCI, AD and cognitively normal. Blood buffy coats were cultured and stained using new methods.
Histologic slides from archived AD brains were stained for the presence of Mycobacteria L-forms.
Results:
MCI=36/36 blood cultures positive
AD=14/14 positive
Elderly controls=52/52 positive
AD Brain Tissue=10/10 samples positive for CWDM
Conclusions: Elderly people have Mycobacteria L-forms in blood macrophages. Patients with Alzheimer’s disease
have what appears to be.. View More»
DOI:
10.35248/2475-3181.24.10.283