Journal of Clinical and Experimental Cardiology
Open Access
ISSN: 2155-9880
ISSN: 2155-9880
Department of Clinical and Experimental Medicine, Careggi University Hospital, Florence, Italy
Research Article
Extracellular Matrix Remodeling and Inflammation in Transthyretin Amyloidosis
Author(s): Alessia Argirņ, Giulia Guidotti, Martina Berteotti*, Viola Liberati, Mattia Zampieri, Federico Perfetto, Marco Allinovi, Anna Poggesi, Carlo Di Mario, Rossella Marcucci and Francesco Cappelli
Introduction and objectives: Transthyretin Amyloid Cardiomyopathy (ATTR-CM) is an interstitial disease characterized by extracellular deposition of amyloid fibrils. The purpose of the study was to assess if inflammation and Extracellular Matrix (ECM) markers are altered in ATTR, as already known for light chain amyloidosis.
Methods: Fourty-nine patients with ATTR-CM were enrolled in an observational, prospective, cross-sectional, single- center study and underwent clinical, instrumental and biohumoral markers evaluation. The laboratory results were compared to those of an age and sex-matched cohort of 50 patients with sole atrial fibrillation.
Results: Mean age was 78 ± 5 years and 83% of patients were men. Forty-two (86%) had acquired ATTR, 7 (14%) had hereditary ATTR. Patients with ATTR-CM presented higher.. View More»
DOI:
10.35248/2155-9880.24.15.895