Journal of Cancer Science and Research
Open Access
ISSN: 2576-1447
ISSN: 2576-1447
Department of Oncology, University Campus Bio-Medico of Rome, Italy
Research
COPD exacerbations affect clinical outcome in advanced non small cell lung cancer: a retrospective analysis
Author(s): Aldo Pezzuto, Alessandro Mazzocca*, Angelo Onorato, Silvia Spoto, Pier Filippo Crucitti and Giuseppe Tonini
Background: Non small cell lung cancer is the leading cause of cancer death worldwide. The increasing life expectancy is due to the improvement in medical treatments including the target therapy, immunotherapy and the maintenance therapy. COPD is a disease often associated and it is characterized over the course by symptoms exacerbations. Chronic Obstructive Pulmonary Disease (COPD) is widely accepted to be an indipendent risk factor for lung cancer.
Objective: The aim of the present study was to determine the effects of COPD exacerbations on the outcome of patients treated with cisplatin-pemetrexed in metastatic lung adenocarcinoma. The main endpoint was to detect the effects of COPD exacerbations on time to progression (TTP). The secondary endpoint was to highlight the effects of exacerbations on treatment toxicity.
Metho.. View More»
DOI:
10.35248/2576-1447.22.7.507