Journal of Clinical Toxicology
Open Access
ISSN: 2161-0495
ISSN: 2161-0495
Department of Physiological Sciences, Santa Casa de São Paulo School of Medical Sciences, São Paulo, SP, Brazil
Research Article
Non-Clinical Evidence Supports Anti-Inflammatories as More Effective Medication than Antihistamines against Tarantula Local Effects Envenomation
Author(s): Bruno Ricardo Alves, Rafael Sutti, Pedro Ismael Da Silva Jr, Rogerio Bertani, Jair Guilherme Santos-Junior, Thomaz Augusto Alves Rocha e Silva and Alessandra Linardi*
Background: Tarantulas are the most common invertebrates pets, especially in North America and Europe. The most commercialized genera are from Southern Asia and tropical Americas, represented by Vitalius, found in Southeastern Brazil, and Brachypelma, common in Mexican desert. Bites by these spiders in humans occurs during manipulation and generally result in clinical manifestations such local pain, erythema and oedema, with the possibility of secondary local infection. Hence, the cases are usually treated with prescription free drugs such as antihistamines and anti-inflammatories.
Methods: In this work, we investigated the post treatment with commercial nonsteroidal and steroidal anti- inflammatories and anti-histamines administered by oral and intraperitoneal routes on rat paw oedema induced by venoms of Vit.. View More»