Drug Designing: Open Access
Open Access

Biology Research Department, Academies of Loudoun in Ashburn, Virginia, United States

Publications

• Research   
  A Molecular Docking Approach to the Drug Inhibition of Endothelial Cell Adhesion Molecules Associated with Small Cell Lung Cancer Progression
  Author(s): Akshay P. Kulakarni*
  
  Small Cell Lung Cancer (SCLC) is a multistage, aggressive, metastatic form of lung cancer that accounts for about 13% of all lung cancer cases, with a 5-year survival rate of less than 6% mainly due to its metastatic component. The focus of metastatic SCLC has been focused on inhibiting the communication between SCLC circulating tumor cells and Cell Adhesion Molecules (CAMs) on endothelial cells, which cancer cells utilize to facilitate transmigration into a secondary tissue site after detaching from the primary tumor. It is well known that multiple CAMs are involved in SCLC transmigration; however, due to the different structures of CAM superfamilies involved in communication, efficient inhibitors to multiple CAMs have not been recognized. This study presents an in silico, molecular modeling approach to find potent inhibitors to multiple cell adhesion molecules i.. View More»
  DOI: 10.35248/2169-0138.21.10.e187

  Abstract HTML PDF