Journal of Pharmaceutical Care & Health Systems
Open Access
ISSN: 2376-0419
ISSN: 2376-0419
Department of Internal Medicine, University of Hospital Centre Mother Teresa, Rruga e Dibres, Tirana AL, Albania
Case Report
Long-Term Clozapine Treatment and Chronic Lymphocytic Leukemia: A Case Report
Author(s): Adela Perolla*
Background: Clozapine is an a typical antipsychotic drug, without extrapyramidal side effects, showing potential for
the treatment of resistant forms of schizophrenia, which affects approximately 30% of patients diagnosed with this
disease. The risk of agranulocytosis encountered in patients using clozapine is not the only reason that psychiatrists
hesitate. Moreover has been observed a correlation between clozapine use and the development of lymphomas and
even acute leukemia in some patients.
We present a 47-years-old patient diagnosed with Treatment-Resistant Schizophrenia (TRS) on clozapine medication
for almost eight years, who developed Chronic Lymphocytic Leukemia (CLL). We also performed a literature review
using the pubmed database regarding the hematological malignancy induced effects of clozapine in long-term
treatment-resistant .. View More»
DOI:
10.35248/2376-0419.23.10.265