Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
+44 1478 350008
ISSN: 2161-1017
+44 1478 350008
Zakaria M Hindi
Hamad Medical Corporation, Hamad General Hospital,
Doha
Qatar
Case Report
Atypical Presentation of Giant Prolactinoma: Case Report and Review of Literature
Author(s): Yanal Mufeed Al-Nimer, Zakaria M Hindi and Tushar KhannaYanal Mufeed Al-Nimer, Zakaria M Hindi and Tushar Khanna
Background: Prolactin is a well-known hormone that mainly functions as a milk producer. Its secretion by lactotroph cells in the pituitary gland (anterior pituitary) is under regulation by different effectors, mainly by Dopamine. However, under non-physiologic circumstances, Prolactin can be over secreted (hyper-prolactinemia) either due to primary (such as pituitary adenoma) or secondary (such as hypothyroidism, infections and systemic diseases) causes. Since prolactin has actions on glucose and lipid metabolisms, hyper-prolactinemia can result in insulin resistance and worsening of lipid profile. In case of prolactinoma, Prolactin can be co-secreted with Growth Hormone in 25% of cases (since lactotroph cells as well as somatotroph cells share common genetic origin), which can have a detrimental additive effect on insulin sensitivity and lipid profile.
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DOI:
10.4172/2161-1017.1000170