Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
Yu-Feng Wang
School of Basic Medical Sciences Harbin Medical University,
157 Baojian Rd, Nangang, Harbin, Heilongjiang 150081
China
Review Article
Model Roles of the Hypothalamo-Neurohypophysial System in Neuroscience Study
Author(s): Dan Hou, Feng Jin, Jiaoyan Li, Jie Lian, Mingyang Liu, Xinna Liu, Yanan Xu, Chaoyu Zhang, Chen Zhao, Shuwei Jia, Runsheng Jiao, Xiaoyu Liu, Xiaoran Wang, Ying Zhang and Yu-Feng WangDan Hou, Feng Jin, Jiaoyan Li, Jie Lian, Mingyang Liu, Xinna Liu, Yanan Xu, Chaoyu Zhang, Chen Zhao, Shuwei Jia, Runsheng Jiao, Xiaoyu Liu, Xiaoran Wang, Ying Zhang and Yu-Feng Wang
Studies on the Hypothalamo-Neurohypophysial System (HNS) have played a pivotal role in establishing the fundamental principles of neuroscience. Examples include the identification of excitation-secretion coupling, the coexistence of peptides-containing large dense core vesicles with classical neurotransmitters, neuronal-glial interactions, functions associated morphological plasticity, and domain-specific regulation of the secretory activity, etc. Moreover, mechanisms underlying the secretion by the HNS and functions of neuropeptides oxytocin and vasopressin remain the central topic of the neuroendocrine society, novel findings of which keep substantiating the model role of this system. Nevertheless, challenges are still severe in this study field, such as extrahypothalamic connections of the HNS, scaffolding and guiding roles of glial fibrillary acidic protein in astrocyte plasticity.. View More»
DOI:
10.4172/2167-0501.1000211