Biochemistry & Pharmacology: Open Access
Open Access

Wang X

Publications

• Review Article
  Ischemia-reperfusion Injury in the Brain: Mechanisms and Potential Therapeutic Strategies
  Author(s): Lin L, Wang X and Yu ZLin L, Wang X and Yu Z
  
  Ischemia-reperfusion injury is a common feature of ischemic stroke, which occurs when blood supply is restored after a period of ischemia. Reperfusion can be achieved either by thrombolysis using thrombolytic reagents such as tissue plasminogen activator (tPA), or through mechanical removal of thrombi. Spontaneous reperfusion also occurs after ischemic stroke. However, despite the beneficial effect of restored oxygen supply by reperfusion, it also causes deleterious effect compared with permanent ischemia. With the recent advancement in endovascular therapy including thrombectomy and thrombus disruption, reperfusion-injury has become an increasingly critical challenge in stroke treatment. It is therefore of extreme importance to understand the mechanisms of ischemia-reperfusion injury in the brain in order to develop effective therapeutics. Accumulating ex.. View More»
  DOI: 10.4172/2167-0501.1000213

  Abstract PDF

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