Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
+44 1478 350008
ISSN: 2161-1017
+44 1478 350008
Vohl MC
Institute of Nutrition and Functional Foods (INAF), Pavillon des Services, 2440 Hochelaga Blvd,
Québec, Québec
Canada
Research Article
Common Sequence Variants in CD163 Gene are Associated with Plasma Triglyceride and Total Cholesterol Levels in Severely Obese Individuals
Author(s): Guénard F, Cormier M, Tchernof A, Deshaies Y, Biron S, Lescelleur O, Biertho L, Marceau S, Pérusse L and Vohl MCGuénard F, Cormier M, Tchernof A, Deshaies Y, Biron S, Lescelleur O, Biertho L, Marceau S, Pérusse L and Vohl MC
Objective: The CD163 glycoprotein is a member of the scavenger receptor cysteine-rich superfamily acting as an inflammatory modulator inducing anti-inflammatory pathways. Previous findings from our group identified this gene as being differentially expressed in visceral adipose tissue (VAT) of severely obese men with vs. without the metabolic syndrome. The current study aimed to test the association between CD163 gene polymorphisms and obesity-related metabolic complications.
Methods: Sequencing of the CD163 gene region was conducted in 25 severely obese individuals. Eleven tagging SNPs (tSNP) were selected and tested for association with obesity-related complications in nearly 1900 severely obese individuals. To further explore potential mechanisms underlying associations identified, the impact of tSNPs on methylation levels of 3 CpG sites .. View More»
DOI:
10.4172/2161-1017.1000146