Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
+44 1478 350008
ISSN: 2161-1017
+44 1478 350008
Vinícius Novaes Rocha
Biomedical Center, Institute of Biology, State University of Rio de Janeiro,
Rio de Janeiro
Brazil
Research Article
Beneficial Effects of Rosuvastatin in Heart of C57Bl/6 Mice with Diet- Induced Metabolic Syndrome - A Preliminary Study
Author(s): Vinícius Novaes Rocha, Rodrigo Neto Ferreira, Carlos Alberto Mandarim-de-Lacerda and Jorge José de CarvalhoVinícius Novaes Rocha, Rodrigo Neto Ferreira, Carlos Alberto Mandarim-de-Lacerda and Jorge José de Carvalho
Background: There is a significant association between the prevalence of cardiovascular disease and metabolic syndrome. Evidence shows that obesity is associated with structural and functional changes in the heart. Estatin drugs can reduce the endogenous synthesis of cholesterol and possess properties that are independent of their effects on lipids, the so-called pleiotropic effects. The present work aims to study the effects of rosuvastatin on the heart of mice with diet-induced metabolic syndrome, such as tissue remodeling and ultrastructural changes.
Methods: In this work we studied the effects of rosuvastatin treatment on the body mass, blood lipids, blood pressure, cardiac remodeling and structure, as well as the ultrastructural changes on the heart of the C57BL/6 male mice fed with a high-fat diet.
Results: T.. View More»
DOI:
10.4172/2161-1017.1000121