Gynecology & Obstetrics
Open Access
ISSN: 2161-0932
ISSN: 2161-0932
Veena Maheshwari
India
Research Article
Apoptotic Index and Mib-1 Antibody Expression in Premalignant and Malignant Lesions of Uterine Cervix
Author(s): Kanupriya Gupta, Kiran Alam, Veena Maheshwari, Roobina Khan and Rajyashri SharmaKanupriya Gupta, Kiran Alam, Veena Maheshwari, Roobina Khan and Rajyashri Sharma
Introduction: Cervical cancers are the second most frequent type of female cancer, responsible for about 5% of cancer deaths in females worldwide. Recently, parameters of cell proliferation and cell death have emerged as important diagnostic and prognostic tools.
Aims: The aim was to evaluate the role of Apoptotic Index and Ki-67 as proliferation marker in premalignant and malignant lesions of uterine cervix. Materials and Methods: The study included 179 patients of cervical dysplasias and malignancy. Evaluation of Apoptotic Index (using light microscopy) was performed on hematoxylin and eosin-stained sections. Ki-67 (MIB-1 antibody) expression was both graded as well as Labelling Index was calculated. Statistical evaluation was carried out using the Student t test (p<0.05).
Results: There was increase in mean Apopt.. View More»
DOI:
10.4172/2161-0932.1000173