Gynecology & Obstetrics
Open Access
ISSN: 2161-0932
ISSN: 2161-0932
Tofan Widya Utami
Indonesia
Research Article
NK-Cell Count and Its Function in Producing Interferon Gamma Associated with the Cervical Cancer Natural History
Author(s): Tofan Widya Utami and Matthew Mindo ParsaoranTofan Widya Utami and Matthew Mindo Parsaoran
Objective: Natural killer cell (NK-cell) has an important role in tumor immunosurveilance. We investigate the NKcell count and its function in producing IFN-γ on normal cervix, subclinical high risk-HPV (hr-HPV) infection, precancerous lesion of cervix, and cervical cancer in order to understand the natural history of uterine cervical cancer.
Methods: This is a descriptive comparative numerical study with more than two unpaired group with total subjects of 40 females who met the inclusion and exclusion criteria. Samples were gathered from cervical tissue using cytobrush and were processed in the laboratory to calculate NK-cell count and NK-cell expression of IFN-γ by phyta hemagglutinin (PHA) stimulation using flow cytometry. Data was analyzed using Kruskal Wallis and post hoc analysis was done to determine the difference between.. View More»
DOI:
10.4172/2161-0932.1000462