Biochemistry & Pharmacology: Open Access
Open Access
ISSN: 2167-0501
+44-20-4587-4809
ISSN: 2167-0501
+44-20-4587-4809
Thorsten Lau
Central Institute of Mental Health, Medical Faculty Mannheim, University Heidelberg,
Germany
Short Communication
Self-Sufficient Stem Cells: Stem Cell-Derived Serotonergic Neurons Rely on Endogenous BDNF Release to Establish Serotonergic Networks during Terminal Differentiation
Author(s): Eva Krause, Patrick Schloss and Thorsten LauEva Krause, Patrick Schloss and Thorsten Lau
The neurotransmitter serotonin plays an essential role in a variety of physiological processes including learning and memory, mood, and neuromodulation. Consequently, dysfunction of serotonergic neurotransmission is associated with psychiatric diseases such as depression, anxiety disorders, and schizophrenia. Because the small number and vast arborization of serotonergic neurons in vivo impede their use in primary cell culture, stem cell-derived serotonergic neurons are applied as in vitro-models for serotonergic neurotransmission. Among others, 1C11 stem cells are used to generate serotonergic neurons in vitro, for example, to analyze the effect of antidepressant treatment on serotonin re-uptake or the function of microRNAs in serotonergic neurons. Since 1C11 stem cells differentiate uniformly into serotonergic neurons, there is no need to optimize terminal differentiation. Therefore.. View More»
DOI:
10.4172/2167-0501.1000194