Dr. Takashi Jin has developed novel nano-bio probes for visualization of molecular and cellular dynamics in biological systems. His research team synthesize a variety of nano-bio-probes such as single-molecule imaging probes using quantum dots, cellular environment-sensitive probes, and cellular-state controllable probes using external magnetic fields. Furthermore, he will develop deep-tissue imaging probes to visualize cellular dynamics in vivo. We synthesize multi-colored fluorescent probes that emit NIR light (1000-1500 nm; the second optical window in living tissues), using cyanine dyes, fluorescent proteins, quantum dots, and rare-earth ions. By using the NIR fluorescent probes, cancer metastasis and immune reactions in vivo will be visualized at the cellular level. He along with his team are also developing probe delivery techniques using DDS for targeting cancer tissues and organs in small animals.
Research Interest
Multi-colored single-molecule imaging probes with high brightness and photo-stability
Cellular-environment sensitive near-infrared probes that respond to membrane potential, pH, and solvent polarity
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