Biochemistry & Pharmacology: Open Access

Biochemistry & Pharmacology: Open Access
Open Access

ISSN: 2167-0501

+44-77-2385-9429

Stefan U Weber

Stefan U Weber
Department of Anesthesiology and Intensive Care Medicine, University Bonn Medical Center,
Sigmund-Freud-Str. 25, 53105 Bonn
Germany

Publications
  • Research Article
    Statins Downregulate the Constitutive Expression of HLA-DR and Reduce Intracellular CD74 in the Monocyte Cell Line Mono Mac 6
    Author(s): Stefan U Weber, Lutz E Lehmann, Makbule Kobilay, Frank Stüber and Andreas HoeftStefan U Weber, Lutz E Lehmann, Makbule Kobilay, Frank Stüber and Andreas Hoeft

    Background: Statins exert immune effects and have been shown to strongly inhibit the interferon-γ induced expression of the human leukocyte antigen (HLA) DR. Monocyte HLA-DR is decreased severe in sepsis and indicates hypo inflammatory and immunosuppressive phases. The aim of the study was to investigate the statin-induced regulation of constitutive HLA-DR expression on monocytes. Method: Monocytes and the monocyte cell line Mono Mac 6 were incubated with simvastatin, mevastatin, pravastatin and fluvastatin. HMG-Coenzyme A reductase was inhibited by l-mevalonate. Protein expression of HLA-DR, Major histocompatibility complex, invariant CD74 and apoptosis were measured by flow-cytometry. mRNA expression was assessed by PCR. Results: Simvastatin dose dependently reduced the constitutive HLA-DR expression on monocytes starting from 500 n.. View More»
    DOI: 10.4172/2167-0501.1000200

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