Anatomy & Physiology: Current Research
Open Access
ISSN: 2161-0940
+44 1300 500008
ISSN: 2161-0940
+44 1300 500008
Sherif Mohamed Zaki
El-Kasr Al Aini Street, Cairo
Egypt
Research Article
Effect of Cisplatinum on the Liver of the Adult Albino Rat and the Possible Protective Role of Vitamin E (Histological and Ultrastructural Study)
Author(s): Saber Shona, Abdel-Wakeel Essawy, Sherif Mohamed Zaki and Tarek Ibrahim Abd EI-GalilSaber Shona, Abdel-Wakeel Essawy, Sherif Mohamed Zaki and Tarek Ibrahim Abd EI-Galil
Background: Cisplatinum is one of the older chemotherapy drugs which is been used for decades. In spite of its significant anticancer activity, its clinical use is often limited by its undesirable side effects. The liver is known to accumulate significant amounts of cisplatinum thus hepatotoxicity could be associated with cisplatinum treatment.
Aim: The aim of the present study is to detect the histopathological effect of cisplatinum on the liver of the adult albino rat and the possible protective role of vitamin E in prevention of cisplatinum-induced hepatotoxicity.
Material and methods: Thirty adult male albino rats were used in the current study. The rats were divided into3 groups; control, cisplatinum and cisplatinum +vitamin E groups. Histological, transmission electro-microscopic as well.. View More»