Journal of Hepatology and Gastrointestinal disorders

Journal of Hepatology and Gastrointestinal disorders
Open Access

ISSN: 2475-3181

Schwarz KB

Schwarz KB
Johns Hopkins University School of Medicine,
CMSC 2-116, 600 North Wolfe St, Baltimore, Md. 21287

  • Research Article
    Utility of Monitoring Azathioprine Metabolites in the Management of Children with Autoimmune Hepatitis
    Author(s): Jannone G, Kafka K and Schwarz KBJannone G, Kafka K and Schwarz KB

    Aim: Although monitoring of the active metabolite (6-thioguanine or 6-TG) and hepatotoxic metabolite (6 methylmercaptopurine or 6-MMP) of the drugs azathioprine (AZA) or 6-mercaptopurine is well-established in children with inflammatory bowel disease, there is little information about the utility of this practice in children with AIH. Objectives: The purpose of this single center retrospective study was two-fold: 1) To determine if metabolite monitoring (MM) was associated with improved clinical outcome and 2) To determine levels of 6-TG associated with remission. Methods: Chart review was performed of all patients ages 0-21 years at the Johns Hopkins Hospital with definite or probable AIH from 1991 to 2012 seen over two years of follow up. Results: Twenty-one patients with AIH met the in.. View More»
    DOI: 10.4172/2475-3181.1000114

    Abstract PDF

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