Endocrinology & Metabolic Syndrome
Open Access
ISSN: 2161-1017
+44 1478 350008
ISSN: 2161-1017
+44 1478 350008
Ricardo Perez-Fuentes
Benemérita Universidad Autónoma de Puebla,
13 Sur 2901 Col. Volcanes, C.P. 72000, Puebla, Pue
Mexico
Research Article
c.+62G>A and g.-420C>G RETN Polymorphisms and the Risk of Developing Type 2 Diabetes and Obesity: Original Research on a Mexican Population and Meta-analysis
Author(s): Pablo A. Montiel-Tellez BS, Adriana Nieva-Vazquez, Leonardo M. Porchia, Elba Gonzalez-Mejia M, Enrique Torres-Rasgado, Guadalupe Ruiz-Vivanco and Ricardo Perez-FuentesPablo A. Montiel-Tellez BS, Adriana Nieva-Vazquez, Leonardo M. Porchia, Elba Gonzalez-Mejia M, Enrique Torres-Rasgado, Guadalupe Ruiz-Vivanco and Ricardo Perez-Fuentes
Objective: To determine the association between the c.+62G>A and g.-420C>G polymorphisms and Type 2 Diabetes (T2D) or obesity susceptibility for Mexicans. Additionally, we examined their overall effect across different populations by a systematic review.
Methods: 164 Mexicans were classified as Healthy, Obese, or T2D. Genotypes were determined and associated risk for the heterozygous, homozygous, dominant, recessive, and allelic genetic models were determined by calculating the Odds Ratios (OR). For the meta-analysis, original publications that had determined RETN polymorphisms in T2D or obese subjects were searched for in PubMed, Scopus, EBSCO, Ovid, and Wiley databases until November 2015, using the search terms: T2D, obesity, RETN, and polymorphism. Pooled ORs were computed using a random-effects or fixed-effects models.
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DOI:
10.4172/2161-1017.1000228